Key result
Muscle LIM protein (MLP) functions as a critical cardiac mechanosensor at the sarcomeric Z-disc and costameres, with mutations or deficiency leading to severe forms of cardiomyopathy and heart failure.
Population
Model organisms and humans with heart failure or cardiomyopathy
Design
Review
Authors
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MLP mechanosensing informs cardiomyopathy mechanisms; leaves open targeted therapies pending prospective validation.
MLP plays a critical role in cardiac mechanosensation, and its mutations or deficiency are linked to the development of hypertrophic and dilated cardiomyopathies.
Buyandelger et al. (2011) conducted a review in Cardiomyopathy and heart failure. Muscle LIM protein (MLP) was evaluated. Muscle LIM protein (MLP) functions as a critical cardiac mechanosensor at the sarcomeric Z-disc and costameres, with mutations or deficiency leading to severe forms of cardiomyopathy and heart failure.
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