Key result
Computational modeling indicates that only about 15% of transcytosolic energy transport is carried by phosphocreatine, contradicting the phosphocreatine shuttle hypothesis, and suggests creatine kinase primarily acts as a temporal energy buffer.
Population
Mathematical model of the compartmentalized creatine kinase system in myocardium, based on multiscale data…
Comparison
In silico inhibition of creatine kinase isoforms… vs Baseline/wild-type CK activity
Design
Preclinical
Authors
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Questions the phosphocreatine shuttle in computational models; hypothesis-generating for myocardial energetics and should not yet change practice.
The study suggests that creatine kinase acts primarily as a high-capacity temporal energy buffer rather than a spatial energy transporter (phosphocreatine shuttle) in the myocardium.
Hettling et al. (2011) studied Myocardial energy metabolism. In silico creatine kinase inhibition vs. Wild-type creatine kinase activity was evaluated on Contribution of phosphocreatine (PCr) to the transfer of high-energy phosphate from mitochondria to sites of ATP hydrolysis. Computational modeling indicates that only about 15% of transcytosolic energy transport is carried by phosphocreatine, contradicting the phosphocreatine shuttle hypothesis, and suggests creatine kinase primarily acts as a temporal energy buffer.
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