Why the study?
Does hydrochlorothiazide-induced volume depletion and subsequent losartan administration affect fibrinolytic function in healthy volunteers?
Does hydrochlorothiazide-induced volume depletion and subsequent losartan administration affect fibrinolytic function in healthy volunteers?
Volume depletion induced by hydrochlorothiazide increases PAI-1, an effect that is blunted by acute administration of losartan, suggesting angiotensin II type 1 receptor involvement in regulating fibrinolytic function.
No takes yet. Share an insight, caveat, or question.
May elevate PAI-1 in healthy volunteers without immediate clinical implications; leaves open losartan's role in modulating fibrinolytic balance.
Lottermoser et al. (2000) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: