Key result
ACE inhibition with quinapril significantly reduced morning PAI-1 antigen concentrations during low salt intake compared to low salt intake alone (16.3 vs 22.7 ng/mL; P<0.05).
Why the study?
Does ACE inhibition with quinapril reduce PAI-1 antigen and activity in normotensive subjects under low salt conditions?
Does ACE inhibition with quinapril reduce PAI-1 antigen and activity in normotensive subjects under low salt conditions?
Absolute Event Rate: 16.3% vs 22.7%
p-value: p=<0.05
ACE inhibition blunts the morning peak in PAI-1, providing a potential mechanism for the reduction of thrombotic cardiovascular events by ACE inhibitors.
No takes yet. Share an insight, caveat, or question.
May modulate fibrinolytic balance in low-salt settings; hypothesis-generating and should not yet change practice.
Brown et al. (1998) studied Normotension. Quinapril vs. Absence of quinapril was evaluated on Mean morning PAI-1 antigen concentration (p=<0.05). ACE inhibition with quinapril significantly reduced morning PAI-1 antigen concentrations during low salt intake compared to low salt intake alone (16.3 vs 22.7 ng/mL; P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: