Why the study?
Do ACE inhibitors and AT1 receptor antagonists differ in their effects on plasma fibrinolytic balance in normotensive subjects?
Population
25 normotensive subjects
Comparison
Quinapril + low salt intake OR Losartan + low… vs Low salt intake alone (10 mmol Na/d)
Design
Other
Authors
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Divergent fibrinolytic effects are hypothesis-generating; leaves open clinical relevance for thrombotic risk in hypertension.
Do ACE inhibitors and AT1 receptor antagonists differ in their effects on plasma fibrinolytic balance in normotensive subjects?
ACE inhibitors and AT1 receptor antagonists have differing effects on fibrinolytic balance during RAAS activation, with quinapril lowering PAI-1 and losartan lowering tPA.
Brown et al. (1999) studied this question.
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