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Rabbit liver mitochondria contain K which cannot be removed by repeated washings with NaCl solutions at 2°C. This K fraction exchanges with ambient K under appropriate metabolic conditions, indicating a dependence of K metabolism on aerobic oxidation. Orthophosphate depresses the mitochondrial K level. A newly observed poly-phasic action of DNP indicates a specific relationship between mitochondrial ester phosphate and K exchange.
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Mudge et al. (1953) studied this question.
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