What question did this study set out to answer?

To determine whether maternal testosterone and estradiol levels measured during early pregnancy correlate with digit ratios (2D:4D) in offspring at 18–22 months of age.

August 9, 2022Scientific ReportsOpen Access

Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy

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Authors

GRGareth RichardsNewcastle University EAEzra AydinIcahn School of Medicine at Mount Sinai ATAlex TsompanidisUniversity of Cambridge

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Implication

Pre-registered study finds inconsistent associations between maternal pregnancy sex hormones and digit ratios in toddlers, suggesting finger length is an unreliable marker for prenatal androgens.

Key Points

To determine whether maternal testosterone and estradiol levels measured during early pregnancy correlate with digit ratios (2D:4D) in offspring at 18–22 months of age.
Conducted a pre-registered prospective study evaluating maternal testosterone (T) and estradiol (E) concentrations during early pregnancy.
Measured offspring right-hand digit ratio (R2D:4D), left-hand digit ratio (L2D:4D), and directional asymmetry (D[R-L]) at 18–22-month follow-up.
Evaluated associations using multivariate analyses adjusted for demographic and obstetric covariates.
Negative correlations between maternal T:E ratio and both right-hand digit ratio (R2D:4D) and directional asymmetry (D[R-L]) lost statistical significance after controlling for demographic and obstetric covariates.
Multivariate analysis showed maternal testosterone correlated negatively with directional asymmetry (D[R-L]) but positively with left-hand digit ratio (L2D:4D), directly contradicting theoretical predictions.

Cite This Study

Richards et al. (2022) studied this question.

synapsesocial.com/papers/6a752cfa01b447f0dadc070e https://doi.org/10.1038/s41598-022-17247-3

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Implication

Pre-registered study finds inconsistent associations between maternal pregnancy sex hormones and digit ratios in toddlers, suggesting finger length is an unreliable marker for prenatal androgens.

Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy

Discussion

Member takes

Implication

Key Points

Cite This Study

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