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April 16, 2013Vector-Borne and Zoonotic DiseasesOpen Access

Diversity of the 47-kD HtrA Nucleic Acid and Translated Amino Acid Sequences from 17 Recent Human Isolates of Orientia

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Population

17 patient isolates of Orientia from Thailand, Laos, Australia, and the United Arab Emirates and 9 reference…

Design

Preclinical

Authors

JJJu JiangNanjing University of Chinese MedicineDPDaniel H. ParisSwiss Tropical and Public Health InstituteSBStuart D. BlacksellThe University of Sydney

Discussion

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Implication

Antigenic variation may require multivalent vaccines; animal data leaves open human translation and optimal design.

Structured PICO

P
Population
17 patient isolates of Orientia from Thailand (n=13), Laos (n=2), Australia (n=1), and the United Arab Emirates (UAE) (n=1) and 9 reference strains
I
Intervention
Sequencing of the full open reading frame (ORF) of the 47-kD HtrA gene and analysis of translated amino acid sequences
O
Outcome
Percentage identity (similarity) of translated amino acid sequencessurrogate

The diversity of Orientia 47-kD HtrA among human isolates highlights the need for a broadly protective scrub typhus vaccine that accounts for this antigenic variation.

Cite This Study

Jiang et al. (2013) studied this question.

synapsesocial.com/papers/6a7536830b1b00a0ee092b73https://doi.org/10.1089/vbz.2012.1112
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