Population
Human blood monocytes and platelets from healthy volunteers
Comparison
NS-398 and L-745,337 incubated with whole blood… vs Ketoprofen
Design
Preclinical
Authors
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Should not yet influence NSAID selection; supports further research into COX-2 selective agents.
L-745,337 and NS-398 are highly selective inhibitors of human monocyte PGHS-2 (COX-2) compared to PGHS-1 (COX-1).
Panara et al. (1995) studied this question.
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