Oxytocin in brain neurons is secreted somato-axono-dendritically and CD38-dependent fashion into the brain and released from the nerve terminals in the posterior pituitary into the circulation.Regarding possible candidates, we suspected the receptor for advanced glycation end-products (receptor for AGEs, RAGE) transports OT from the peripheral blood into the brain by RAGE in endothelial cells at the BBB.
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Higashida et al. (2022) studied this question.
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