May 22, 2014Diabetes

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

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Why the study?

Does the curcumin analog C66 prevent high glucose-induced inflammation and diabetic cardiomyopathy in preclinical models?

Population

H9c2 cells, neonatal cardiomyocytes, and mice with type 1 diabetes

Comparison

C66 or SP600125 at 5 mg/kg vs Untreated high glucose conditions or untreated…

Design

Preclinical

Authors

YPYong PanShenzhen University YWYi WangMacau University of Science and Technology YZYunjie ZhaoNorth China University of Technology

Discussion

Member takes

Implication

Supports JNK inhibition as a target in diabetic cardiomyopathy models; leaves open translation to human therapy.

Structured PICO

Does the curcumin analog C66 prevent high glucose-induced inflammation and diabetic cardiomyopathy in preclinical models?

Population

H9c2 cells, neonatal cardiomyocytes, and mice with type 1 diabetes

Intervention

C66 (a novel curcumin derivative) or SP600125 (JNK inhibitor) at 5 mg/kg

Comparator

Untreated high glucose conditions (in vitro) or untreated type 1 diabetes mice (in vivo)

Outcome

Inflammatory cytokine levels, apoptosis, histological abnormalities, fibrosis, and cardiac dysfunctionsurrogate

The novel curcumin analog C66 protects against diabetic cardiomyopathy by inhibiting JNK phosphorylation, reducing inflammation and apoptosis.

Cite This Study

Pan et al. (2014) studied this question.

synapsesocial.com/papers/6a753db0756843cacbb1f043 https://doi.org/10.2337/db13-1577

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Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of JNK Phosphorylation by a Novel Curcumin Analog Prevents High Glucose–Induced Inflammation and Apoptosis in Cardiomyocytes and the Development of Diabetic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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