Why the study?
Does cardiac contractility modulation improve outcomes and reverse cardiac remodeling in patients with chronic heart failure?
Does cardiac contractility modulation improve outcomes and reverse cardiac remodeling in patients with chronic heart failure?
Cardiac contractility modulation represents a promising device-based therapeutic option for patients with chronic heart failure, particularly those with a narrow QRS complex who are ineligible for cardiac resynchronization therapy.
This review highlights the preclinical and clinical data about a relatively new electrophysiological method for chronic heart failure (CHF) treatment, cardiac contractility modulation (CCM). The review presents efficacy and safety data. An updated information about the capability of CCM to influence the molecular genetic apparatus of the cardiomyocytes is proposed. In addition, the review assesses prospects for application of CCM as a tool for reverse cardiac remodeling in patients with CHF.
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Ryabov et al. (2019) studied this question.
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