Why the study?
Does exercise preconditioning reduce cardiac doxorubicin accumulation and preserve cardiac function in Sprague-Dawley rats?
Population
Sprague-Dawley rats (n=207)
Comparison
10 weeks of exercise prior to doxorubicin… vs Sedentary group receiving the same doxorubicin…
Design
Preclinical, Randomly assigned to 1 of 3 primary experimental groups
Follow-up
Up to 9 days after doxorubicin exposure
Authors
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Exercise preconditioning merits investigation for doxorubicin cardiotoxicity; hypothesis-generating in rats and requires human trials before any practice consideration.
Does exercise preconditioning reduce cardiac doxorubicin accumulation and preserve cardiac function in Sprague-Dawley rats?
Exercise preconditioning may protect against doxorubicin-induced cardiotoxicity by reducing myocardial accumulation of the drug.
Jensen et al. (2013) studied this question.
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