What question did this study set out to answer?

To determine how aging affects cholesterol saturation of bile, hepatic secretion of biliary lipids, and bile acid synthesis.

August 1, 1985New England Journal of Medicine

Influence of Age on Secretion of Cholesterol and Synthesis of Bile Acids by the Liver

View Full Paper

Ask AI

Bookmark

Authors

KEKurt EinarssonLinköping University KNK NilsellKarolinska University Hospital BLBarbro LeijdSaint Göran Hospital

Discussion

Member takes

Implication

Cross-sectional study reveals increased biliary cholesterol saturation and decreased bile acid synthesis with age in healthy adults, explaining why aging raises gallstone risk.

Key Points

To determine how aging affects cholesterol saturation of bile, hepatic secretion of biliary lipids, and bile acid synthesis.
Analyzed lipid composition of stimulated duodenal bile in 60 healthy, non-obese subjects without gallstones (31 men, 29 women) across various ages.
Measured hepatic secretion rates of biliary lipids in 22 subjects and quantified cholic acid and chenodeoxycholic acid kinetics in 18 subjects.
Age correlated positively with cholesterol saturation of bile (P < 0.001) and hepatic cholesterol secretion rates (r = 0.48).
Age correlated negatively with total bile acid synthesis (r = -0.60) and cholic acid pool size (r = -0.54).

Cite This Study

Einarsson et al. (1985) studied this question.

synapsesocial.com/papers/6a7547f0a44b96c1f7dbf573 https://doi.org/10.1056/nejm198508013130501

View Full Paper

Ask AI

Bookmark

Implication

Cross-sectional study reveals increased biliary cholesterol saturation and decreased bile acid synthesis with age in healthy adults, explaining why aging raises gallstone risk.

Influence of Age on Secretion of Cholesterol and Synthesis of Bile Acids by the Liver

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of Age on Secretion of Cholesterol and Synthesis of Bile Acids by the Liver

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider