Population
Cultured smooth muscle cells from rat aorta
Comparison
Angiotensin peptides (AI, AII, AIII) vs Control conditions and various inhibitors
Design
Preclinical
Authors
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Caution against extrapolating these cell findings to patients; leaves open the role of angiotensin in human vascular Na+ regulation.
Angiotensin peptides activate an amiloride-sensitive Na+ transporter in vascular smooth muscle cells, which subsequently increases Na+/K+ pump activity by supplying its rate-limiting substrate.
Smith et al. (1983) studied this question.
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