Why the study?
Does cilazapril or TCV-116 improve glomerular injury in Dahl salt-sensitive rats on a high-salt diet?
Does cilazapril or TCV-116 improve glomerular injury in Dahl salt-sensitive rats on a high-salt diet?
In a rat model of salt-sensitive hypertension, AT1 receptor antagonism provided superior renoprotection compared to ACE inhibition by reducing proteinuria and glomerular TGF-beta1 levels independently of blood pressure reduction.
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AT1 antagonism may confer added renoprotection in salt-sensitive models; hypothesis-generating and requires human trials before any clinical consideration.
Otsuka et al. (1998) studied this question.
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