Why the study?
Do different antihypertensive drugs (atenolol, nitrendipine, lisinopril) affect radial artery compliance compared to placebo in normotensive volunteers?
Population
32 normotensive volunteers
Comparison
100 mg atenolol, 20 mg nitrendipine, or 20 mg… vs Placebo orally once a day for 8 days
Design
RCT, randomly allocated, double-blind
Follow-up
8 days
Authors
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Lisinopril acutely enhances radial compliance unlike other agents; extends evidence for ACEI-specific vascular effects in normotensive volunteers.
Do different antihypertensive drugs (atenolol, nitrendipine, lisinopril) affect radial artery compliance compared to placebo in normotensive volunteers?
Lisinopril, but not atenolol or nitrendipine, acutely increases radial artery diameter and compliance in normotensive volunteers.
Perret et al. (1991) studied this question.