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November 24, 2018Journal of Clinical MedicineOpen Access

There were no between-group differences in the changes in arterial stiffness (median PWV difference −0.034, 95% CI −0.42 to 0.36 m/s; p = 0.860) at week 12, but the exercise group significantly increased cardiorespiratory fitness (median difference 2.26 minutes, 95% CI 0.98 to 3.55; p = 0.001).

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Why the study?

The study evaluated the effect of a 12-week aerobic exercise program on arterial stiffness, inflammation, oxidative stress, and cardiorespiratory fitness in women with systemic lupus erythematosus.

Does 12 weeks of aerobic exercise improve arterial stiffness, inflammation, oxidative stress, and cardiorespiratory fitness in women with systemic lupus erythematosus?

Population

58 women with systemic lupus erythematosus

Comparison

12-week aerobic exercise vs usual care

Design

Non-randomized clinical trial

Follow-up

12 weeks

Authors

ASAlberto Soriano‐MaldonadoPMPablo Morillas‐de‐LagunoJSJosé Mario Sabio

Discussion

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Member takes

Overview

Aerobic exercise appears safe for fitness gains in SLE women; leaves open arterial stiffness benefits pending RCTs.

Structured PICO

Does 12 weeks of aerobic exercise improve arterial stiffness, inflammation, oxidative stress, and cardiorespiratory fitness in women with systemic lupus erythematosus?

P
Population
58 women with systemic lupus erythematosus (SLE)
I
Intervention
12 weeks of progressive treadmill aerobic exercise (2 sessions × 75 min/week) between 40–75% of the individual’s heart rate reserve
C
Comparator
Usual care
O
Outcome
Arterial stiffness assessed through pulse wave velocity (PWV) at week 12surrogate

12 weeks of progressive treadmill aerobic exercise increases cardiorespiratory fitness without exacerbating arterial stiffness, inflammation, or oxidative stress in women with SLE.

Cite This Study

Soriano‐Maldonado et al. (2018) studied this question.

synapsesocial.com/papers/6a75599701b447f0dadc16e1https://doi.org/10.3390/jcm7120477
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise2020 · 12 citations
  2. 2Increased aortic pulse wave velocity in middle aged women with systemic lupus erythematosus2006 · 51 citations
  3. 3Using exercise training to counterbalance chronotropic incompetence and delayed heart rate recovery in systemic lupus erythematosus: A randomized trial2012 · 79 citations
  4. 4Femoral artery remodeling after aerobic exercise training without weight loss in women2008 · 16 citations
  5. 5Effect of an 11-Week Resistance Training Program on Arterial Stiffness in Young Women2022 · 9 citations