November 9, 2022Frontiers in PhysiologyOpen Access

Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats

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Why the study?

It was unknown whether central interventions targeting TACE activity attenuate neuroinflammation and improve cardiac function in heart failure.

Population

Myocardial infarction-induced HF or sham-operated rats

Comparison

TACE siRNA microinjection or ICV TAPI-0 infusion vs scrambled siRNA or sham

Design

Animal experimental study

Follow-up

4 weeks

Authors

YYYang YuUniversity of Iowa BXBaojian XueUniversity of Iowa NINafis Md. IrfanUniversity of Iowa

Discussion

Member takes

Implication

Hypothesis-generating in rodent heart failure models; leaves open clinical translation of TACE inhibition.

Structured PICO

Population

Myocardial infarction-induced heart failure (HF) or sham-operated (SHAM) rats

Intervention

Bilateral paraventricular nucleus microinjection of a TACE siRNA or a 4-week intracerebroventricular (ICV) infusion of the TACE inhibitor TAPI-0

Comparator

Sham-operated rats or scrambled siRNA-treated HF rats

Outcome

Neuroinflammation markers (TACE levels, TNF-α, TNF-α receptor 1, cyclooxygenase-2, p-NF-κB p65, ERK1/2), sympathetic excitation, and cardiac function (LVEDP, pulmonary congestion, cardiac hypertrophy, fibrosis)surrogate

Suppressing TACE activity in the brain mitigates neuroinflammation, sympathetic activation, and cardiac dysfunction in a rat model of heart failure.

Cite This Study

Yu et al. (2022) studied this question.

synapsesocial.com/papers/6a75599ef1e99ff85ab1e371 https://doi.org/10.3389/fphys.2022.1052304

View Full Paper

Ask AI

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Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reducing brain TACE activity improves neuroinflammation and cardiac function in heart failure rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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