Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells*

Shaoxin Zheng; Changqing Zhou; Yinlun Weng; Hui Huang; Hao Wu; Jing Huang; Wei Wu; Shijie Sun; Jingfeng Wang; Wanchun Tang; Tong Wang

doi:10.1097/ccm.0b013e318206d6e8

January 18, 2011Critical Care Medicine

Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells*

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Why the study?

Does allogeneic cardiac stem cell transplantation improve electrophysiologic stability and ventricular fibrillation threshold in a rat model of myocardial infarction?

Key Points

To assess electrophysiologic characteristics and the ventricular fibrillation threshold in a rat myocardial infarction model following allogeneic cardiac stem cell transplantation.
Study of 20 male Sprague-Dawley rats with induced myocardial infarction.
Two weeks post-infarction, rats were randomized to receive intramyocardial injection of either 5 × 10^6 PKH26-labeled cardiac stem cells (n=10) or phosphate buffer solution alone (n=10).
Electrophysiologic properties and ventricular fibrillation thresholds were assessed across infarct, marginal, and noninfarct zones six weeks post-injection.
Activation recovery time dispersions were significantly shorter in the cardiac stem cell group compared to the control group (15.5 ± 4.4 vs. 38.6 ± 14.9 ms, p = .000177).
Malignant ventricular arrhythmias were significantly less inducible in the cardiac stem cell group than in the control group (1 of 10 [10%] vs. 9 of 10 [90%], p = .00108).
Ventricular fibrillation thresholds improved after stem cell delivery, with grafted cells in infarct and border zones expressing Connexin-43, von Willebrand factor, α-smooth muscle actin, and α-sarcomeric actin.

Structured PICO

Does allogeneic cardiac stem cell transplantation improve electrophysiologic stability and ventricular fibrillation threshold in a rat model of myocardial infarction?

P

Population

20 male Sprague-Dawley rats with induced myocardial infarction

I

Intervention

5 × 10^6 allogeneic cardiac stem cells labeled with PKH26 in phosphate buffer solution injected into the infarcted anterior ventricular-free wall 2 weeks post-myocardial infarction

C

Comparator

Phosphate buffer solution-alone injection into the infarcted anterior ventricular-free wall

O

Outcome

Electrophysiologic characteristics (unipolar electrogram activation recovery time dispersions) and ventricular fibrillation threshold at 6 weeks post-injectionsurrogate

Implication

Allogeneic cardiac stem cell transplantation improves electrophysiologic stability and reduces the inducibility of malignant ventricular arrhythmias in a rat model of myocardial infarction.

Abstract

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Cite This Study

Zheng et al. (2011) studied this question.

synapsesocial.com/papers/6a755b6c99129e9915f5816b https://doi.org/10.1097/ccm.0b013e318206d6e8

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Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells*

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Improvements of cardiac electrophysiologic stability and ventricular fibrillation threshold in rats with myocardial infarction treated with cardiac stem cells*

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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