October 28, 2006Journal of Lipid ResearchOpen Access

Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mice

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Structured PICO

Population

Mice lacking endogenous hepatic lipase and the low density lipoprotein receptor (LDLr-KOxHL-KO) fed a regular chow diet

Intervention

Expression of catalytically active hepatic lipase (HL-WT) or inactive hepatic lipase (HL-S145G)

Comparator

LDLr-KOxHL-KO mice without hepatic lipase expression

Outcome

Atherosclerosis (measured by cross-sectional and en face analysis) and lipoprotein metabolism (cholesterol, non-HDL-cholesterol, and apolipoprotein B levels)surrogate

Both the lipolytic and ligand-binding functions of hepatic lipase independently protect against atherosclerosis in LDL receptor-deficient mice via non-LDLr pathways.

Discussion

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Implication

Both hepatic lipase functions may independently protect against atherosclerosis in mice; leaves open human translation.

Cite This Study

Freeman et al. (2006) studied this question.

synapsesocial.com/papers/6a755f04e2936089dd033ad3 https://doi.org/10.1194/jlr.m600321-jlr200

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