Why the study?
The role of adipocytokines in carcinogenesis is not fully understood, particularly in challenging gynecological cancers such as ovarian and endometrial cancer.
This review summarizes the current understanding of how various adipocytokines influence the tumor microenvironment in ovarian and endometrial cancers.
Adipocytokines may influence ovarian cancer via the tumor microenvironment; leaves open their therapeutic relevance pending prospective validation.
Due to their multidirectional influence, adipocytokines are currently the subject of numerous intensive studies. Significant impact applies to many processes, both physiological and pathological. Moreover, the role of adipocytokines in carcinogenesis seems particularly interesting and not fully understood. For this reason, ongoing research focuses on the role of these compounds in the network of interactions in the tumor microenvironment. Particular attention should be drawn to cancers that remain challenging for modern gynecological oncology-ovarian and endometrial cancer. This paper presents the role of selected adipocytokines, including leptin, adiponectin, visfatin, resistin, apelin, chemerin, omentin and vaspin in cancer, with a particular focus on ovarian and endometrial cancer, and their potential clinical relevance.
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Stępień et al. (2023) studied this question.
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