Why the study?
The study aimed to evaluate the possible effects of Huangqi Jianzhong Tang (HQJZT) on cardiac function and related mechanisms in acute myocardial infarction.
Does Huangqi Jianzhong Tang improve cardiac function and reduce infarct size in a rat model of acute myocardial infarction?
Does Huangqi Jianzhong Tang improve cardiac function and reduce infarct size in a rat model of acute myocardial infarction?
The traditional Chinese medicine formulation HQJZT improved cardiac function and reduced myocardial apoptosis in a rat model of acute myocardial infarction.
High-dose HQJZT improved cardiac function in AMI rats; hypothesis-generating and requires clinical trials before any therapeutic consideration.
Huangqi Jianzhong Tang (HQJZT) is a traditional Chinese herbal formula consisting of seven different herbs: Radix Astragali, Radix Paeoniae Alba, Ramulus Cinnamomi, Fructus Jujubae, Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle, Rhizoma Zingiberis Recens, and Saccharum Granorum. The present study aims to evaluate the possible effects of HQJZT on cardiac function in acute myocardial infarction (AMI) and related mechanism. AMI model was established by ligation of the left anterior descending coronary artery followed by one-week HQJZT treatment. Survival rate was calculated. Rat heart function was assessed by heart performance analysis system. 5-Triphenyltetrazolium chloride (TTC) staining was used to observe myocardial infarct size. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining and western blot were applied to evaluate tissue apoptotic level. Treatment with high dose of HQJZT improved cardiac function, reduced infarct size, number of apoptotic cells and expression of apoptotic proteins, Bax (a proapoptotic protein), and increased expression of antiapoptotic protein, Bcl2. However, enalapril (an angiotensin-converting enzyme inhibitor) treatment did not show marked improvement of these parameters. Our present data suggest that HQJZT has potential therapeutic effects to improve cardiac function by regulation of apoptotic signaling pathway.
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Bao et al. (2020) studied this question.
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