Why the study?
Does hypereosinophilic syndrome affect left atrial volumetric and strain parameters assessed by 3DSTE compared to healthy controls?
Does hypereosinophilic syndrome affect left atrial volumetric and strain parameters assessed by 3DSTE compared to healthy controls?
Hypereosinophilic syndrome is associated with increased left atrial volumes and reduced circumferential strain, suggesting significant left atrial remodeling and dysfunction.
3DSTE LA parameters may differ in HES; hypothesis-generating and requires larger prospective studies before any clinical role.
Introduction The present study was designed to compare three-dimensional speckle tracking echocardiography (3DSTE)-derived left atrial (LA) volumetric, volume-based functional and strain parameters between patients with hypereosinophilic syndrome (HES) and matched controls. Methods A total of 10 HES patients and 19 age- and gender-matched healthy controls were included in the study. Complete two-dimensional Doppler echocardiography and 3DSTE were performed in all HES cases and controls. Results Significantly increased maximum (72.9±38.8 ml vs. 45.6±15.5 ml, p=0.01) and minimum (46.3±33.3 ml vs. 26.0±15.0 ml, p=0.03) LA volumes and LA volume before atrial contraction (62.0±36.0 ml vs. 36.5±16.6 ml, p=0.01) were found in HES patients compared to controls. Both peak global (18.3±6.7% vs. 25.6±9.0%, p=0.03) and mean segmental (22.2±6.0% vs. 31.0±12.1%, p=0.04) circumferential strains were significantly reduced in HES patients, suggesting decreased LA reservoir function. Conclusion Increased LA volumes can be demonstrated in HES patients, accompanied by reduced LA peak circumferential strain as assessed by 3DSTE, suggesting LA remodeling.
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Nemes et al. (2016) studied this question.
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