Why the study?
Osteoglycin is implicated in cardiac dysfunction and adverse remodeling after myocardial infarction, but the underlying mechanism remains to be elucidated.
Does Osteoglycin silencing inhibit myocardial fibrosis and EMT/EndMT in a mouse model of myocarditis?
Population
Mice with myocarditis
Comparison
Ogn gene silencing vs control
Design
Preclinical animal study
Authors
Loading...
Does not support Ogn targeting in human myocarditis; leaves open whether Wnt modulation affects clinical fibrosis.
Does Osteoglycin silencing inhibit myocardial fibrosis and EMT/EndMT in a mouse model of myocarditis?
Osteoglycin silencing inhibits myocardial fibroblast proliferation and EMT/EndMT via the Wnt signaling pathway in a mouse model of myocarditis, suggesting a potential therapeutic target.
Fang et al. (2020) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: