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January 1, 2018Arquivos Brasileiros de CardiologiaOpen Access

Secondary Dyslipidemia In Obese Children - Is There Evidence For Pharmacological Treatment?

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Why the study?

Do statins improve surrogate markers of coronary artery disease and lipid profiles in children and adolescents with dyslipidemia secondary to obesity?

Population

Children and adolescents with dyslipidemia secondary to obesity

Design

Systematic_review

Authors

GRGraciane RadaelliInstituto do CérebroGSGrasiele SausenBrigham and Women's HospitalCCCláudia Ciceri CesaInstituto Federal Sul-rio-grandense

Discussion

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Implication

No RCTs support statin use for obesity-related pediatric dyslipidemia; leaves open need for trials before any pharmacological consideration.

Structured PICO

Do statins improve surrogate markers of coronary artery disease and lipid profiles in children and adolescents with dyslipidemia secondary to obesity?

P
Population
Children and adolescents with dyslipidemia secondary to obesity
I
Intervention
Statins
O
Outcome
Improvement of surrogate markers of coronary artery disease in clinical outcomes of adulthood; increased serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipropotein B (APOB); and decreased serum levels of high-density lipoprotein cholesterol (HDL-C)surrogate

There is currently no randomized clinical trial evidence to support the use of statins for treating hypercholesterolemia secondary to obesity in children.

Cite This Study

Radaelli et al. (2018) studied this question.

synapsesocial.com/papers/6a7563938d2049c8dd03749dhttps://doi.org/10.5935/abc.20180155

Topics

Lipid managementStatin therapy
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