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March 12, 2010Preventive CardiologyOpen Access

Risk Factors for Subclinical Carotid Atherosclerosis Among Current Smokers

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Population

1504 current smokers, 58% female, median age 44.7 years, median 25 pack-years.

Design

Cross-sectional

Authors

HJHeather M. JohnsonGeneral CardiologyMPMegan E. PiperUniversity of Wisconsin–MadisonDJDouglas E. JorenbyUniversity of Wisconsin–Madison

Discussion

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Implication

May inform smoker risk stratification; leaves open whether small LDLs or pack-years causally drive plaque.

Structured PICO

P
Population
1504 current smokers, 58% female, median age 44.7 years, median 25 pack-years.
O
Outcome
Carotid intima-media thickness (CIMT) and carotid plaque presencesurrogate

In current smokers, pack-years, age, BMI, and small LDLs are independently associated with subclinical carotid atherosclerosis, with smoking history having a stronger effect on plaque presence in women.

Cite This Study

Johnson et al. (2010) studied this question.

synapsesocial.com/papers/6a75641099129e9915f585c2https://doi.org/10.1111/j.1751-7141.2010.00068.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carotid artery intimal-medial thickness distribution in general populations as evaluated by B-mode ultrasound. ARIC Investigators.1993 · 726 citations
  2. 2Ultrasound-detected carotid plaque as a predictor of cardiovascular events2006 · 99 citations
  3. 3Prediction of Clinical Cardiovascular Events With Carotid Intima-Media Thickness2007 · 2,979 citations
  4. 4Association between Multiple Cardiovascular Risk Factors and Atherosclerosis in Children and Young Adults1998 · 4,019 citations
  5. 5The Fagerström Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire1991 · 10,877 citations