This review highlights the mechanisms and risks of serious acquired-prothrombotic states that can paradoxically develop during treatment with common anticoagulants like heparin and warfarin.
Warrants vigilance for paradoxical prothrombotic events during anticoagulation; leaves open incidence, mechanisms, and prevention strategies.
EACH YEAR THROMBOEMBOLISM affects millions of individuals worldwide. As a result, anticoagulants are among the most commonly prescribed drugs in clinical practice. Heparin sodium and warfarin sodium are used alone or sequentially for primary and secondary prophylaxis in the management of a variety of thrombotic diseases. Bleeding complications associated with these agents are well-known; however, the risks and causes of paradoxical venous or arterial thrombosis occurring during anticoagulant therapy have only recently been elucidated. This article reviews the current understanding of serious acquired-prothrombotic states that can occasionally develop during treatment with anticoagulants. As background, a brief description of each drug’s mechanism of action is first presented.
No takes yet. Share an insight, caveat, or question.
J. O. Ballard (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: