Heparin and warfarin are commonly used for treating and preventing thromboembolic conditions and require monitoring via aPTT and PT.
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Emphasizes need for vigilant monitoring in thromboembolic therapy; leaves open comparative effectiveness with modern anticoagulants.
Heparin and warfarin sodium (Coumadin, Panwarfin, Sofarin) are used most often to treat acute and recurrent venous thromboembolic disease, arterial disease, valvular heart disease, and atrial fibrillation. These agents along with dextran, pneumatic compression devices, and gradient stockings are also used to prevent deep venous thrombosis and pulmonary embolism in patients at high risk (eg, those with venous stasis, lower limb or spinal cord trauma, clotting abnormalities). Anticoagulation therapy is monitored by maintaining the activated partial thromboplastin time and the prothrombin time in the therapeutic range.
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Dhami et al. (1991) studied this question.
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