Key result
Genetic factors influence systolic blood pressure and renal-hormonal sodium handling independent of body size.
Observational
Answers are grounded in this paper and cite their sources.
Utilization of several genetic models (twins, families of monozygotic twins, characterized hypertensives and normotensive first-degree-relatives of essential hypertensives) has permitted us to probe for evidence of genetic mediation of several components of the blood pressure control system in humans. These studies have identified evidence for genetic mediation of systolic blood pressure in a cross-sectional study of normotensive subjects covering a wide age span. Further, this effect was independent of body size. The twin model, studied under conditions of sodium loading and sodium and volume depletion, demonstrated a genetic component in the response of plasma renin activity, aldosterone, norepinephrine and renal sodium excretion to these maneuvers. Among hypertensive subjects and unexpected abnormality in the distribution of a specific MNS blood group pattern was seen in renal vascular hypertensives. This may provide a new genetic marker for identifying individuals at increased risk to develop this abnormality.
No takes yet. Share an insight, caveat, or question.
Weinberger et al. (1981) conducted an observational in Hypertension and blood pressure control. Genetic factors and sodium loading/depletion maneuvers was evaluated on Systolic blood pressure and neurohormonal/renal responses (plasma renin activity, aldosterone, norepinephrine, renal sodium excretion). Genetic factors mediated systolic blood pressure independently of body size, as well as hormonal and renal responses to sodium loading and depletion.
Synapse has enriched 10 related papers. Consider them for comparative context: