Key result
IV sodium loading proportionately increases sodium and water excretion with worsening hypertension and renal vascular resistance.
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Excretion of infused sodium, chloride, and water increased proportionately in patients with progressively more severe grades of hypertension and of increased renal vascular resistance. These relationships held so long as renal plasma flow and glomerular filtration rate were not greatly impaired. The abnormality was characterized by increased renal tubular rejection of sodium, chloride and water.
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Cottier et al. (1958) studied this question. Intravenous sodium chloride loading proportionately increased urinary excretion of sodium, chloride, and water in patients with progressively more severe hypertension and renal vascular resistance.
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