Key result
Splanchnicectomy transiently blunts the exaggerated natriuretic response to salt loading in hypertensive patients.
Observational
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Under the stress of acute hypertonic salt loading, hypertensives excrete sodium at a much greater rate than normotensives. Immediately following splanchnicectomy, sodium excretion is markedly reduced in the hypertensive, but after several months it returns toward preoperative levels. There appears to be a rough correlation between maximum rate of sodium excretion and mean blood pressure. Normotensives by contrast exhibit insignificant differences pre- and postoperatively.
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Thompson et al. (1954) conducted an observational in Hypertension. Acute hypertonic salt loading before and after splanchnicectomy vs. Normotensive surgical patients was evaluated on Urinary sodium excretion rate. Acute hypertonic salt loading caused much greater sodium excretion in hypertensives vs normotensives, which markedly dropped immediately after splanchnicectomy before returning toward baseline.
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