Why the study?
Does intravenous scopolamine alter heart rate response and R-R variance during postural changes in healthy male volunteers?
Does intravenous scopolamine alter heart rate response and R-R variance during postural changes in healthy male volunteers?
Low-dose intravenous scopolamine produces vagomimetic effects on heart rate and R-R variance during postural changes in healthy volunteers.
Low-dose scopolamine enhances vagal HR modulation during postural changes; extends resting-state observations to dynamic conditions in healthy volunteers.
To examine the anticholinergic effects of scopolamine, postural tests were performed in nine healthy male volunteers after they received intravenous infusions of 0.2mg of scopolamine, 0.4 mg of glycopyrrolate, or placebo on separate days under double‐blind randomized conditions. Compared to the placebo and glycopyrrolate conditions, scopolamine produced a significantly exaggerated HR response to standing from supine posture. Scopolamine also produced a significant increase in R‐R variance during supine deep breathing and standing conditions as compared to glycopyrrolate and placebo conditions. At the same time, scopolamine also produced a significant dry mouth. These findings suggest that the effects of scopolamine in low doses on the above cardiac variables are vagomimetic.
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Yeragani et al. (1992) studied this question.
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