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September 7, 2005Journal of Biological ChemistryOpen Access

Stimulatory Roles of Nitric-oxide Synthase 3 and Guanylyl Cyclase in Platelet Activation

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Population

Platelets and in vivo thrombosis model

Design

Preclinical

Authors

JMJasna MarjanovicUniversity of Illinois Urbana-ChampaignZLZhenyu LiHong Kong Polytechnic UniversityASAleksandra StojanovićCentre for Mental Health

Discussion

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Implication

Challenges view of NO as purely inhibitory in platelets; leaves open human relevance of NOS3 in thrombosis.

Structured PICO

P
Population
Platelets and in vivo thrombosis model
I
Intervention
Low doses of platelet agonists activating NOS3
O
Outcome
Platelet secretion, aggregation, and in vivo thrombosissurrogate

The study reveals a novel biphasic role for nitric oxide in platelet activation, where low concentrations stimulate secretion and aggregation via NOS3 and cGMP, challenging the prevailing concept that NO is purely inhibitory.

Cite This Study

Marjanovic et al. (2005) studied this question.

synapsesocial.com/papers/6a75662c0081fe7b05dc1bbfhttps://doi.org/10.1074/jbc.m506518200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet inhibiton by sodium nitroprusside, a smooth muscle inhibitor1976 · 54 citations
  2. 2Activated platelets express IL-1 activity.1989 · 126 citations
  3. 3Nitric oxide released from activated platelets inhibits platelet recruitment.1997 · 392 citations
  4. 4Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.1992 · 993 citations
  5. 5A Redox Site Involved in Integrin Activation2000 · 144 citations