July 1, 1997Diabetes
Long-Term Effect of Lisinopril and Atenolol on Kidney Function in Hypertensive NIDDM Subjects With Diabetic Nephropathy
Why the study?
Does lisinopril reduce the rate of decline in kidney function more than atenolol in hypertensive NIDDM patients with diabetic nephropathy?
Population
43 hypertensive NIDDM patients with diabetic nephropathy
Comparison
Lisinopril 10-20 mg/day for up to 42 months vs Atenolol 50-100 mg/day for up to 42 months
Design
RCT, randomized, parallel, double blind for the first 12 months and single…
Follow-up
up to 42 months
Authors
Discussion
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Member takes
Implication
Both equally slow GFR decline in hypertensive diabetic nephropathy; confirms comparable renoprotection despite superior albuminuria reduction with lisinopril.
Structured PICO
Does lisinopril reduce the rate of decline in kidney function more than atenolol in hypertensive NIDDM patients with diabetic nephropathy?
P
Population
43 hypertensive NIDDM patients with diabetic nephropathy (data presented for 36 patients who completed at least 12 months, mean age 60 +/- 7 years, 27 men)
I
Intervention
Lisinopril 10-20 mg/day for up to 42 months
C
Comparator
Atenolol 50-100 mg/day (usually in combination with a diuretic) for up to 42 months
O
Outcome
Rate of decline in kidney function (glomerular filtration rate)surrogate
Lisinopril and atenolol are equally effective in reducing the rate of decline in kidney function in hypertensive NIDDM patients with diabetic nephropathy, although lisinopril provides a greater reduction in albuminuria.
Cite This Study
Nielsen et al. (1997) studied this question.