Why the study?
Does the response of neonatal myeloid DC to HCMV infection differ from adult myeloid DC?
Population
Cord and adult blood-derived myeloid dendritic cells (DC)
Comparison
In vitro human CMV (HCMV) infection vs Adult blood-derived myeloid DC compared to…
Design
Preclinical
Authors
Loading...
Neonatal DC impairment may underlie HCMV susceptibility in infants; hypothesis-generating for human studies and interventions.
Does the response of neonatal myeloid DC to HCMV infection differ from adult myeloid DC?
Neonatal myeloid dendritic cells exhibit deficient IL-12 and mature IFN-alpha production in response to HCMV infection compared to adult cells, potentially explaining neonatal susceptibility to severe HCMV disease.
Renneson et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: