Why the study?
Blood lipids play a critical role in health and disease, but the interplay of genetics and environment within the broader blood lipidome is less explored.
Population
Healthy older-aged twins (75 monozygotic/55 dizygotic pairs) in the Older Australian Twins Study
Design
Twin study
Authors
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Heritable lipids in older twins should not yet alter clinical lipid management; leaves open gene-environment and epigenetic contributions to the plasma lipidome.
A subset of plasma lipids, including ceramides and triglycerides, are significantly heritable in older adults, demonstrating a complex interplay of genetic and environmental influences on the ageing plasma lipidome.
Wong et al. (2020) studied this question.
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