Why the study?
Pulmonary arterial hypertension is a fatal cardiopulmonary disease whose incidence rate is affected by age, motivating study of age-related mechanisms.
Does age affect survival and disease progression in monocrotaline-induced pulmonary hypertensive rats?
Does age affect survival and disease progression in monocrotaline-induced pulmonary hypertensive rats?
Age significantly impacts survival in the monocrotaline-induced rat model of pulmonary arterial hypertension, with young rats experiencing much earlier mortality than adult rats despite similar molecular changes.
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Kawade et al. (2021) studied this question.
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