The growth response to high-dose growth hormone (GH) therapy was investigated in 10 short, prepubertal, slowly-growing children. Two years treatment with recombinant human GH at a dose of 0.3 IU/kg daily 7 days per week resulted in a mean height increase of 19.5 cm (range 17-23 cm). There was a slight but not significant acceleration of bone age maturation. The treatment also induced a sustained increase in insulin secretion without detectable changes in glucose tolerance.
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Pierre Bougnères (1990) studied this question.
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