Population
Single frog muscle fibres selected for low resting tension
Comparison
Sarcomere isometric contractions vs Fixed-end tetani contractions
Design
Preclinical
Authors
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Reinforces filament overlap as force determinant in isometric conditions; leaves open translation to mammalian cardiac sarcomeres in vivo.
The study confirms that the linear descending limb of the force-sarcomere length relation is a characteristic feature of isometrically contracting sarcomeres in frog muscle fibers.
Granzier et al. (1990) studied this question.
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