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April 1, 1990AJP Endocrinology and Metabolism

Triglyceride kinetics, tissue lipoprotein lipase, and liver lipogenesis in septic rats

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Population

Lewis inbred rats, 275-300 g

Comparison

Sepsis induced by 8 x 10 live E. coli colonies… vs Control rats (fasted and fed)

Design

Preclinical

Follow-up

24 hours

Authors

SLSusan Lanza‐JacobyThomas Jefferson UniversityATA. TabaresThomas Jefferson University

Discussion

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Implication

Hypothesis-generating for LPL-targeted approaches in sepsis; should not yet inform human management.

Structured PICO

P
Population
Lewis inbred rats, 275-300 g
I
Intervention
Sepsis induced by 8 x 10(7) live E. coli colonies per 100 g body wt
C
Comparator
Control rats (fasted and fed)
O
Outcome
VLDL-TG kinetics (clearance and production), lipoprotein lipase (LPL) activities, and liver lipogenesissurrogate

Gram-negative sepsis in rats induces hypertriglyceridemia primarily through decreased peripheral clearance of VLDL-TG and suppressed lipoprotein lipase activity.

Cite This Study

Lanza‐Jacoby et al. (1990) studied this question.

synapsesocial.com/papers/6a756ec6e239d27fbe033371https://doi.org/10.1152/ajpendo.1990.258.4.e678
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypertriglyceridemia Produced by Endotoxin: Role of Impaired Triglyceride Disposal Mechanisms1976 · 114 citations
  2. 2Coated Charcoal Immunoassay of Insulin1965 · 2,995 citations
  3. 3Quantitative Determination of Serum Triglycerides by the Use of Enzymes1973 · 3,202 citations
  4. 4A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION1959 · 23,249 citations
  5. 5Two dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis of spots1970 · 3,298 citations