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Develop and evaluate a 3D-bioprinted gelatin methacrylate hydrogel patch functionalized with a VEGF-mimicking peptide to promote angiogenesis and accelerate wound closure.

March 24, 2021Biomedical MaterialsOpen Access

Enhanced wound healing using a 3D printed VEGF-mimicking peptide incorporated hydrogel patch in a pig model

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Develop and evaluate a 3D-bioprinted gelatin methacrylate hydrogel patch functionalized with a VEGF-mimicking peptide to promote angiogenesis and accelerate wound closure.
Fabricated porous GelMA hydrogel patches loaded with a VEGF-mimicking peptide using 3D bioprinting based on shear-thinning ink properties.
Assessed in vitro biocompatibility, cell proliferation, and capillary-like tubular formation using NIH 3T3 fibroblasts and human umbilical vein endothelial cells.
Evaluated in vivo wound-healing efficacy using a full-thickness porcine skin wound model.
The 3D-printed hydrogel patch demonstrated high porosity, strong water absorption, and sustained slow release of the VEGF-mimicking peptide.
Peptide-loaded hydrogels significantly promoted fibroblast proliferation and endothelial tubular structure formation in vitro.
Application of the hydrogel patch enhanced tissue repair and wound closure in the pig skin wound model.

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Implication

Preclinical study demonstrates enhanced wound healing with 3D-printed VEGF-mimicking peptide hydrogel patches in a porcine model, indicating therapeutic potential for advanced wound dressings.

Cite This Study

Jang et al. (2021) studied this question.

synapsesocial.com/papers/6a7570f38d2049c8dd037c3b https://doi.org/10.1088/1748-605x/abf1a8

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Implication

Preclinical study demonstrates enhanced wound healing with 3D-printed VEGF-mimicking peptide hydrogel patches in a porcine model, indicating therapeutic potential for advanced wound dressings.

Enhanced wound healing using a 3D printed VEGF-mimicking peptide incorporated hydrogel patch in a pig model

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Discussion

Implication

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Enhanced wound healing using a 3D printed VEGF-mimicking peptide incorporated hydrogel patch in a pig model

Key Points

Discussion

Implication

Cite This Study

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