Why the study?
Does intracoronary infusion of norepinephrine alter the regional distribution of myocardial blood flow in the isolated supported heart preparation?
Population
Isolated supported heart preparation
Comparison
Intracoronary infusion of norepinephrine vs Control conditions
Design
Preclinical
Authors
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May predispose to subendocardial ischemia under catecholamine stress; hypothesis-generating in isolated hearts, translation to humans remains open.
Does intracoronary infusion of norepinephrine alter the regional distribution of myocardial blood flow in the isolated supported heart preparation?
Norepinephrine infusion under constant coronary blood flow decreases endocardial perfusion in isolated hearts, suggesting a mechanism for stress-induced subendocardial ischemia.
Warltier et al. (1975) studied this question.
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