What does this research mean for the field?

Radioactive microspheres of 15μ diameter can safely measure regional myocardial blood flow without altering hemodynamics at appropriate doses, revealing that the left ventricular endocardial to epicardial flow ratio is increased by propranolol, decreased by isoprenaline, and unchanged by nitroglycerin. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1971Cardiovascular Research

Regional myocardial blood flow in the dog studied with radioactive microspheres

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Population

Anaesthetized dogs

Design

Preclinical

Authors

NFNicholas J. FortuinCardiac Imaging SKSatoshi KaiharaKobe City Medical Center General Hospital LBL. C. BeckerJohns Hopkins University

Discussion

Member takes

Implication

Animal data suggest beta-adrenergic modulation of transmural flow; hypothesis-generating and leaves open human translation.

Structured PICO

Population

Anaesthetized dogs

Intervention

15 and 50μ radioactive microspheres via left atrial injection, with pharmacological testing (propranolol, isoprenaline, nitroglycerin)

Outcome

Regional myocardial blood flow distribution (ratio of left ventricular endocardium to epicardium)surrogate

Radioactive microspheres effectively measure regional myocardial blood flow, revealing differential effects of propranolol and isoprenaline on endocardial versus epicardial perfusion.

Cite This Study

Fortuin et al. (1971) studied this question.

synapsesocial.com/papers/6a13fe227411b50316625dfe https://doi.org/10.1093/cvr/5.3.331

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