A simple bullfrog heart model with burn-induced subepicardial injury successfully mimics the ST segment elevation seen in human ischemic heart disease, providing a useful experimental tool.
Bullfrog burn model reproduces ST changes; hypothesis-generating and leaves open translation to mammalian ischemia research.
To mimic ischemic heart disease in humans, several animal models have been created, mainly in rodents by surgically ligating their coronary arteries. In the present study, by simply inducing burn injuries on the bullfrog heart, we reproduced abnormal ST segment changes in the electrocardiogram (ECG), mimicking those observed in ischemic heart disease, such as acute myocardial infarction and angina pectoris. The "currents of injury" created by a voltage gradient between the intact and damaged areas of the myocardium, negatively deflected the ECG vector during the diastolic phase, making the ST segment appear elevated during the systolic phase. This frog model of heart injury would be suitable to explain the mechanisms of ST segment changes observed in ischemic heart disease.
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Itsuro Kazama (2015) studied this question.
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