Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1997AJP Cell Physiology

Basis of passive tension and stiffness in isolated rabbit myofibrils

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated rabbit skeletal and cardiac myofibrils

Design

Preclinical

Authors

MBMarc L. BartooUniversity of York
Wolfgang A. Linke
Wolfgang A. LinkeHeart Failure / CardiomyopathyGPGerald H. PollackUniversity of Washington

Discussion

Loading...

Member takes

Implication

Titin dominates passive stiffness in relaxed rabbit myofibrils; leaves open relevance to human cardiac mechanics and cross-bridge contributions.

Structured PICO

P
Population
Isolated rabbit skeletal and cardiac myofibrils
I
Intervention
Mechanical testing in calcium-free, ATP-containing solution under varying ionic strength, temperature, and stretch conditions
O
Outcome
Passive tension and stiffness (contribution of titin filaments vs weakly bound cross bridges)surrogate

In isolated rabbit myofibrils, passive force and dynamic stiffness are primarily determined by the viscoelastic properties of titin filaments rather than weakly bound cross bridges.

Cite This Study

Bartoo et al. (1997) studied this question.

synapsesocial.com/papers/6a75747ef2cd31a1fadc1306https://doi.org/10.1152/ajpcell.1997.273.1.c266
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tension changes during and after stretch in frog muscle fibres1972 · 124 citations
  2. 2Extensible and Less-Extensible Domains of Connectin Filaments in Stretched Vertebrate Skeletal Muscle Sarcomeres as Detected by Immunofluorescence and Immunoelectron Microscopy Using Monoclonal Antibodies11988 · 149 citations
  3. 3Titin: major myofibrillar components of striated muscle.1979 · 548 citations
  4. 4Interplay between passive tension and strong and weak binding cross-bridges in insect indirect flight muscle. A functional dissection by gelsolin-mediated thin filament removal.1993 · 94 citations
  5. 5Elastic filaments in situ in cardiac muscle: deep-etch replica analysis in combination with selective removal of actin and myosin filaments.1993 · 120 citations