SummaryExperimental phenylketonuria has been produced in young rats by feeding excessive quantities of L-phenylalanine. Rats fed 7% L-phenylalanine diet showed consistently high phenylalanine values and increased excretion of urinary phenylketones. When fed in a light-dark room, rats fed 3.5%, 5%, or 7% L-phenylalanine showed reduction in liver phenylalanine hydroxylase as compared with rats fed a normal diet.
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Wang et al. (1961) studied this question.