UJI EFEKTIVITAS ANTIDEPRESAN SUSPENSI EKSTRAK DAUN SIRSAK (Annona muricata, L.) TERHADAP MENCIT PUTIH JANTAN

Depression can be caused by organobiological factors (imbalance of neurotransmitters in the brain due to constriction of blood vessels). Soursop leaves are used in traditional medicine as a sedative. Antidepressant effects on fruit and leaves Soursop caused by three alkaloid compounds which are annonaine, nornuciferine, and asymilobine are tested to mice. Soursop leaf ( Annona muricata, L .) has a reputation as an antidepressant. This study aims to determine the effectiveness of antidepressant suspension of Soursop Leaf extract ( Annona muricata, L .) against white mice by force method. Testing of antidepressants based on immobility time by using the Sand Sand Test method after oral suspension of Soursop Leaf extract ( Annona muricata, L .). Soursop Leaf Extract by extracting simplicia by using 70% alcohol in maceration. The extract is then thickened and formulated into a suspension. Soursop Leaf ( Annona muricata, L .) with concentration of 1.5%, 2.5% and 3.5%, the positive control group is amitriptyline tablet tablet made by suspension and control group that is giving of suspending agent Data were analyzed using SPSS 21.0 using Oneway ANAVA (α = 0,05). The results were shown by suspension of Soursop Leaf extract ( Annona muricata, L .) with concentration of 1.5%, 2.5% and 3.5% had no difference with positive control. Suspension of Soursop Leaf extract ( Annona muricata, L .) with concentration of 1.5%, 2.5% and 3,5% have ability as antidepressant to white mouse with Forced Swimming Test method.