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Nine rats were exposed to 0.8 ppM NO/sub 2/ and allowed to live out life-span of up to 33 months. There were 12 control animals. No emphysema or other overt changes were noted due to exposure. The animals were also normal otherwise except for an increase in respiration rate of about 20% (tachypnea).
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Freeman et al. (1966) studied this question.
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