Radiotelemetry is an effective novel tool for continuous recording of intrathoracic pressure in mice, enabling detailed analyses of circadian rhythms and respiratory pathophysiology.
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No immediate clinical implications in humans; leaves open validation of ITP radiotelemetry for cardiorespiratory research.
We have demonstrated for the first time in mice that radiotelemetry is an effective tool for the continuous and chronic recording of intrathoracic pressure (ITP) to facilitate circadian rhythm analyses. We show that continuous 24-h hypoxic stress alters the circadian rhythms of heart rate, body temperature, activity, and respiratory parameters, acutely and perpetually, through normoxic recovery. Radiotelemetry of ITP can complement traditional methods for evaluating respiratory function and better our understanding of respiratory pathophysiology.
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Foster et al. (2020) studied this question.
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